Major depresyonlu hastalarda amineptinin trazodon ve plasebo ile çift kör karşılaştırmalı bir çalışması
Başlık çevirisi mevcut değil.
- Tez No: 20132
- Danışmanlar: Belirtilmemiş.
- Tez Türü: Tıpta Uzmanlık
- Konular: Psikiyatri, Psychiatry
- Anahtar Kelimeler: Amineptine, Depresif bozukluk, Depresyon, Plasebolar, Trazodon, Amineptine, Depressive disorder, Depression, Placebos, Trazodone
- Yıl: 1991
- Dil: Türkçe
- Üniversite: Atatürk Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
SIII:İEÎ âmineptine vs traaodo&e and placebo İn the treatment of 91 outpatients suffering from riiajoi' depression with respect to the DBM-XXX-B diagnostic criteria tag studâed for @ffieac£, tolerability aad aide effects o This was & double-blin#, randomised study* M tie tit s between the ages of 18 aad 65 years, scoring at least 18 on the 21- item Hamilton Bating Scale for Depression (HESS), following one week placebo washout period, were inciMed in the study* For statistical analysis of data from 91 patients, analysis of variance aad Chi squan test Were u@ed.Both active drags showed significantly superiority to placebo for efficajey (amineptiae vs placebo p 0*05f trazodone v$ placebo p 0.001), trazodone showed also superiority to amineptiae with respect to efficacy on the global improved at the of the etudy, while difference between efficacy of the two active drugs was not statietically significant for HRSB. frasodone and asineptiae groups were showed ©tatisfcieâlüy more ©id© effects than placebo. In trazo done group side effects such as dry south, drowsiness, di^&iness» gastric distress and weakness, were cleared; while in ss&neptine group irritability, appetite loss, insomnia were cleared as well* She most important side effect in 91 patients was two reversible toxic hepatitis cases caused by amineptino. Br.Mte tep AŞKÎI tj^daMİM^iliffl Sala Arş.a&r*
Özet (Çeviri)
S U M M A R Y Amineptine vs trazodone aad placebo in the treatraeat of 91 outpatients sufferiag from majör depressioa with respect to the DSIvi-IIl-R diagaostic criteria ®as studmed for efficacy, tolerability aad side effects. This \vas a double-bliağ, raadomized study. Patieatsl betweea the ages of 18 aad 65 years, scoriag at least 18 on the 21- item lianıilton. Rating Scale for Depressioa (HRSD), following oae v/eek placebo v/aslıout period, were inclîıded in the study. I'or statisisical aaalysis^of data from 91 patients, analysis of variance aad Chi squa3 test were used.Both active drugs shov/ed sigaificantly superiority to placebo for efficajsy (amiaeptiae vs placebo p 0.05^ trazodoae vs placebo p 0.001), trazodoae shov/ed also superiority to amiaeptiae v/ith respect to efficacy oa the global improved at the of the studys v/hile differeace betweea efficacy of the two active drugs was not statistically sigaificaııt for HRSD. Trazodoae aad amiaeptiae groups vj-ere showed statisbiaâlly ınore side effects than placebo, la trazo¬ doae group side effects such as dry mouth, drov/siaess, dizziaess, gastric distress aad v/eakaessj \vere cleared; v/hile i:i amiaeptiae group irritability, appetite loss, iasonıaia were cleared as well. The most importaat side effect ia 91 patieats r/as two reversible tor;ic hepatitis cases caused by amiaeptiae» Dr.Rus teb AŞKIN Böi&iyaAti/A^abilim Dalı Arş.Gör.
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