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Non-invasive monitoring of gastric motility in humans

Mide hareketliliğinin insanlarda müdahalesiz ölçümü-elektrogastrografi

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  1. Tez No: 198801
  2. Yazar: KORAY ÖZCAN
  3. Danışmanlar: YRD. DOÇ. DR. ATA AKIN
  4. Tez Türü: Yüksek Lisans
  5. Konular: Biyomühendislik, Biyoteknoloji, Gastroenteroloji, Bioengineering, Biotechnology, Gastroenterology
  6. Anahtar Kelimeler: Elektrogastrografi (EGG), diken dalga potansiyeli, gastrik motilite, gastrik\DYDúGDOJDOar, Electrogastrography (EGG), spike potential, gastric motility, gastric slow waves
  7. Yıl: 2005
  8. Dil: İngilizce
  9. Üniversite: Boğaziçi Üniversitesi
  10. Enstitü: Biyomedikal Mühendislik Enstitüsü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

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Özet (Çeviri)

ABSTRACTNON-INVASIVE MONITORING OF GASTRIC MOTILITY IN HUMANSStomach is an organ of gastrointestinal system where the food coming from the mouththrough the esophagus is mixed by the rhythmic contractions of the smooth muscles, with acidand other gastric secretions. The control of motility of the stomach is performed by neuronal andhormonal factors that modulate the smooth muscles in generating muscular contractions.Electrogastrography is a procedure for recording gastric myoelectrical activity either invasivelyby placing electrodes on serosal lining of the stomach or non-invasively by using electrodeslocated on the skin of the abdomen. Compared with the development of other surfaceelectrophysiological measurements, such as Electrocardiogram (ECG) and Electroencephalogram(EEG), the progress of the EGG has been very slow. The main problems include: (1) difficulty indata acquisition and analysis because of the low signal-to-noise ratio of the EGG; (2) difficulty ininterpreting EGG data and extracting useful and relevant information from the EGG; and (3) lackof understanding of the correlation between the EGG and gastric motility. Today, numerousclinical and animal studies are being carried out by using EGG in order to have reliable, scientificdata which can help the interpretation of the findings. The frequency of gastric contractions iscontrolled by the gastric slow wave, which is around 3 cycles per minute (cpm) and theappearance of gastric contractions is associated with spike activities. Today, conventional EGGdevices are collecting data related with the lower frequency signals but it was shown on theanimal models that higher frequency signals observed during peristaltic contractions can also bedetected and quantified from EGG recordings by using a suitable method and perhaps, thepatterns of this high frequency components can be correlated with the pathological processesrelated with the stomach. Our main interest arises on the collection and interpretation of the highfrequency peristaltic contractions signals in humans using EGG.

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