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Sağlıklı bireylerde IGF-1 düzeyleri ile endotel disfonksiyonu arasındaki ilişkinin araştırılması ve aterosklerozun bir göstergesi olarak IGF-1

Associaton between serum IGF-1 levels in healthy individuals and endothelial dysfunction,and IGF-1 as a marker of atherosclerosis

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  1. Tez No: 192433
  2. Yazar: FATMA NESLİHAN ÇUHACI
  3. Danışmanlar: PROF.DR. METİN ARSLAN
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Biyokimya, Endokrinoloji ve Metabolizma Hastalıkları, Biochemistry, Endocrinology and Metabolic Diseases
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2006
  8. Dil: Türkçe
  9. Üniversite: Gazi Üniversitesi
  10. Enstitü: Tıp Fakültesi
  11. Ana Bilim Dalı: İç Hastalıkları Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

6$ö/,./,%ø5(</(5'(ø16h/ø1-/ø.(*52:7+)$.7g5-I(IGF-,'h=(</(5øø/((1'27(/'ø6)21.6ø<218$5$6,1'$.øø/øù.ø1ø1$5$ù7,5,/0$6,9($7(526./(52=81%ø5*g67(5*(6ø2/$5$.,*)-I'5)1(6/ø+$1d8+$&,Ateroskleroz; KAH, PDH ve AMI'ne neden olabilen, kompleks ve kronik bir süreçtir.$WHURVNOHUR]XQ JHOLúLPLQGH HUNHQ G|QHPGH ROXúDQ YH PDM|U URO RODQ IDNW|U HQGRWHOGLVIRQNVL\RQXGXU 12 UHWLPLQLQ EX G|QHPGH D]DOGÕ÷Õ ,*F-,¶LQ 12 UHWLPLQL VWLPXOH HWWL÷Lve bu nedenle de IGF-, YH HQGRWHO GLVIRQNVL\RQX GROD\ÕVÕ\OD GD DWHURVNOHUR] JHOLúLPLIGF-, LOH .$+ DUDVÕQGD LOLúNL ROGX÷X \DSÕODQDUDVÕQGD LOLúNL RODELOHFH÷L GúQOPHNWHGLUateroskleroz patogenezinde insülin direnci ve endoteloDOÕúPDODUOD J|VWHULOPLúWLU $\UÕFDGLVIRQNVL\RQXQXQPHUNH]LELUURODOGÕ÷ÕQDGDLUELOJLOHUJLGHUHNDUWPDNWDGÕUIGF-,G]H\LGúN YH \NVHN ¶úHU NLúL LOH QRUPDO RODQ NLúL dahildDOÕúPDPÕ]adüzeyini etkilHGL÷LHGLOPLúWLU dDOÕúPDPÕ]GD VHUXP ,*)-I ELOLQHQ '0 NURQLN NDUDFL÷HUEndotel disfonksiyonununKDVWDOÕ÷ÕYHNURQLNE|EUHNKDVWDOÕ÷ÕRODQODULQFHOHPHGÕúÕEÕUDNÕOGÕ.belirteçlerinden olan NO ve ET-I ile IGF-, DUDVÕQGD YH \LQH HQGRWHO GLVIRQNVL\RQXQDlipid düzeyleri veGROD\ÕVÕ\ODGDDWHURVNOHUR]DNDWNÕVÕROGX÷XELOLQHQULVNIDNW|UOHULQGHQ&53fibrinojen düzeyleri ile IGF-,DUDVÕQGDNLLOLúNLLQFHOHQdi. IGF-I düzeyleri ile NO, ET-I, hs-CRP, fibrinojen ve lipid düzeyleri DUDVÕQGD LOLúNLbulunamaGÕAncak IGF-I düzeyi yüksek olan grupta NO ile TG ve VLDL-.DUDVÕQGD pozitifbir korelasyon tespit edildi. $\UÕFD OLWHUDWU EXOJXODUÕQÕQ WHUVLQH ,*)-, G]H\L GúN RODQpozitifJUXSWD12LOH LQVOLQGLUHQFLDUDVÕQGDLVWDWLVWLNVHORODUDNDQODPOÕIDUNOÕOÕ÷DQHGHQRODQbu grupta endotel disfonksiyonunun belirteçlerinden olan NO ileELU NRUHODV\RQ YDUGÕ YHLDL-K, VLDL-.7*YHWRWDONROHVWHURODUDVÕQGDda DQODPOÕELU LOLúNLEXOXQGXBu bulgular,erken dönemde NO'inEX NDUGL\RYDVNOHU ULVN IDNW|UOHULQLQ DUWÕúÕQD LNLQFLO RODUDN |]HOlikleIGF-I düzeyleri ile hs-CRP,ELU VDYXQPD PHNDQL]PDVÕ RODUDNDUWDELOHFH÷LQL GúQGUPúWUfibrinojen ve lipid düzeyleri DUDVÕQGD ELU LOLúNL EXOXQDPDGÕ DQFDN ,*)-,¶L GúN RODQ JUXSWDfibrinojen düzeyleri daha yüksek bulundu. Yine IGF-,¶L GúNGL÷HU JUXED J|UH KV-CRP,olan grupta ET-I ile hs-&53G]H\LDUDVÕQGDSR]LWLIELULOLúNLVDSWDQGÕ. Bu bulgular ise IGF-IGúNO÷QQ EX EHOLUWHoOHU ]HULQGHQ DWHURVNOHUR]D NDWNÕGD EXOXQDELOHFH÷LQLGúQGUPúWU dDOÕúPDPÕ]ÕQ RULMLQDO EXOJXVX LVH LQVOLQ GLUHQFL LOH 9.ø DUDVÕQGD DQODPOÕbir korelasyon tespit edilmesiydi.Sonuç olarak IGF-,GúNO÷QQHUNHQG|QHPDWHURVNOHUR]XQEHOLUOHQPHVLQHNDWNÕGDEXOXQDELOHFH÷L DQFDN EX NLúLOHULQ X]XQ G|QHPOL WDNLSOHULQLQ \DSÕODFD÷Õ oDOÕúPDODUOD JHUoHNULVNLQRUWD\DNRQDELOHFH÷LGúQOPúWU

Özet (Çeviri)

$662&ø$721%(7:((16(580ø168/ø1-/ø.(*52:7+FACTOR-I (IGF-I)/(9(/6ø1+($/7+<ø1'ø9ø'8$/6$1'(1'27+(/ø$/'<6)81&7ø21 AND IGF-I AS A MARKER OFATHEROSCLEROSø6'5)1(6/ø+$1d8+$&,Atherosclerosis, which may cause coronary artery disease, peripheral artery diseaseand acute myocardial infarction is a complex and chronic process. Endothelial dysfunction isan early and major factor in the development of atherosclerosis. It is considered that, in theHDUO\ VWDWH RI DWKHURVFOHURVLV QLWULF R[LGH 12 SURGXFWLRQ LV UHGXFHG DQG VLQFH øQVXOLQ-likegrowth factor-I (IGF-I) stimulates NO production there is relation between IGF-I andendothelial dysfunction and consequently relation between IGF-I and atherosclerosisdevelopment. It has been shown that there is a relation between IGF-I and coronary arterydisease. Also there is increasing evidence that, insulin resistance and endothelial dysfunctionplay a central role in the pathogenesis of atherosclerosis.Our study include 67 participant, who are divided into three groups according to theirIGF-I levels.There was 17 subject in IGF-I lower group, 17 in the higher and 33 in the normalgroup.Their age was between 40-65 years old, and body mass index < 27 kg/m2 . History ofdiabetes mellitus, chronic liver and kidney disease didn?t accept to the study, because thesediseases can affect IGF-I levels. Also people who have hypertension didn?t take place in thestudy though it is a cardiovascular risk factor. Relationship between IGF-I and NO,Endothelin-I (ET-I), markers of endothelial dysfunction, and also between IGF-I and C-reactive protein (CRP), lipid and fibrinogen levels, risk factors that may contribute to theendothelial dysfunction and atherosclerosis, are investigated.No relationship was found between IGF-I and NO, ET-I,high sensitive CRP (hs-CRP)and lipid levels. But in the IGF-I higher group there was positive correlation between NO andTriglyceride (TG) and Very-Low-Density Lipoprotein Cholesterol (VLDL-C). Also contraryto litheratur findings, in the IGF-I lower group there was significantly positive correlationbetween NO and insulin resistance and also in this group significantly relationship betweenNO and Low-Density Lipoprotein Cholesterol (LDL-C), VLDL-C, TG and total cholesterol.These findings considered us, especially in the early state NO can increase as a defense mechanism secondary to increase of cardiovascular risk factors. No correlation was foundbetween IGF-I and hs-CRP, fibrinogen and lipid levels, but in the IGF-I lower group hs-CRPand fibrinogen were higher than the other two groups. Additionally in the IGF-I lower groupwe determined positive correlation between ET-I and hs-CRP. These findings considered us,reduction of IGF-I levels contribute to atherosclerosis by these marksers. Original finding ofour study was, significant correlation between insulin resistance and body mass index.Consequently, it is considered that reduction of IGF-I may contribute to early state ofatherosclerosis, but to bring out the real risk these people must be followed for a long period.

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