Primer hipertansiyonlu hastalarda mikroalbuminüri ve arteriyel distensibilite ilişkisi
Arteriel distensibility and microalbuminuria relation in patients with primary hypertension
- Tez No: 171550
- Danışmanlar: DOÇ.DR. GÖKHAN NERGİZOĞLU
- Tez Türü: Tıpta Uzmanlık
- Konular: Nefroloji, Nephrology
- Anahtar Kelimeler: Hypertension, microalbuminuria, Pulse Wave Velocity, Hypertension, microalbuminuria, Pulse Wave Velocity
- Yıl: 2006
- Dil: Türkçe
- Üniversite: Ankara Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: İç Hastalıkları Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
SUMMARY ARTERIEL DISTENSIBILITY AND MICROALBUMINURIA RELATION IN PATIENTS WITH PRIMARY HYPERTENSION Systematic arteriel hypertension which is commonly seen in society is one of the most important reasons increasing cardiovascular morbidite and mortality microalbuminuria is known to be an indicator of renal damage in diabetic patients studies carried out indicate that the excretion of increased uriner albumin increases together with the cardiovascular risk in not only diabetics but also hypertensives and even in general population. It's been indicated that Pulse Wave velocity (PWV) and pulse wave analysis which are indicators of arteriel stiffness, the major hemodynamic factor affecting pulse pressure, predict the cardiovascular mortality independently. For the study, 67 hypertensive patients and 73 normotensive control cases who applied to without Diabetes Mellitus and secondary hypertension, not receiving antihypertensive treatment were taken. 24 hours ambulatuar blood pressure observation and PWV measurement was done microalbuminuria levels were observed in 24 hours urine. In the cases, noticable differences regarding ambulatuar blood pressure and measured day systolic blood pressure, diastolic blood pressure, pulse pressure, mean blood pressure, microalbuminuria and pulse wave velocity was observed between the two groups. At the end of the study, as the independent variable of microalbuminuria, PWV (p<0,001) and sistolic blood pressure (p<0,01) were determined; and as the independent variables of PWV, age (p<0,000), systolic blood pressure (p<0,000) and microalbuminuria (p<0,006) were determined. In our study, we found out a close relation between microalbuminuria, an early finding of renal damage, and aortic PWV, an indicator of stiffness of elatic veins. We think that abnormalities observed inthe high blood pressure and function and structure of the kidney are not 26only limted with resistance arteriols and that big vein pathologies should be taken into consideration.
Özet (Çeviri)
SUMMARY ARTERIEL DISTENSIBILITY AND MICROALBUMINURIA RELATION IN PATIENTS WITH PRIMARY HYPERTENSION Systematic arteriel hypertension which is commonly seen in society is one of the most important reasons increasing cardiovascular morbidite and mortality microalbuminuria is known to be an indicator of renal damage in diabetic patients studies carried out indicate that the excretion of increased uriner albumin increases together with the cardiovascular risk in not only diabetics but also hypertensives and even in general population. It's been indicated that Pulse Wave velocity (PWV) and pulse wave analysis which are indicators of arteriel stiffness, the major hemodynamic factor affecting pulse pressure, predict the cardiovascular mortality independently. For the study, 67 hypertensive patients and 73 normotensive control cases who applied to without Diabetes Mellitus and secondary hypertension, not receiving antihypertensive treatment were taken. 24 hours ambulatuar blood pressure observation and PWV measurement was done microalbuminuria levels were observed in 24 hours urine. In the cases, noticable differences regarding ambulatuar blood pressure and measured day systolic blood pressure, diastolic blood pressure, pulse pressure, mean blood pressure, microalbuminuria and pulse wave velocity was observed between the two groups. At the end of the study, as the independent variable of microalbuminuria, PWV (p<0,001) and sistolic blood pressure (p<0,01) were determined; and as the independent variables of PWV, age (p<0,000), systolic blood pressure (p<0,000) and microalbuminuria (p<0,006) were determined. In our study, we found out a close relation between microalbuminuria, an early finding of renal damage, and aortic PWV, an indicator of stiffness of elatic veins. We think that abnormalities observed inthe high blood pressure and function and structure of the kidney are not 26only limted with resistance arteriols and that big vein pathologies should be taken into consideration.
Benzer Tezler
- Primer hipertansiyonlu hastalarda spironolaktonun hedef organ hasarı üzerine etkisinin enalapril ile karşılaştırmalı değerlendirilmesi
Comparison of effects of spironolactone and enalapril on and organ damage in patients with primary hypertension
HASAN TURAN
Tıpta Uzmanlık
Türkçe
2001
KardiyolojiAnkara Üniversitesiİç Hastalıkları Ana Bilim Dalı
DOÇ.DR. KENAN ATEŞ
- Primer hipertansiyonda perindopril-indapamid kombine tedavisinin kan basıncı, mikroalbuminüri ve transforming growth faktör-Beta düzeylerine etkileri
Başlık çevirisi yok
ZERRİN BİCİK
Tıpta Yan Dal Uzmanlık
Türkçe
2002
NefrolojiGazi Üniversitesiİç Hastalıkları Ana Bilim Dalı
PROF. DR. ŞÜKRÜ SİNDEL
- Primer hipertansiyonu olan hastalarda endotel disfonksiyonu ve serum vasküler endotelyal growth faktör düzeyleri
Endothelial dysfunction and serum vascular endothelial growth factor levels in patients with primary hypertension
BÜNYAMİN SARITAŞ
Tıpta Uzmanlık
Türkçe
2007
NefrolojiÇukurova Üniversitesiİç Hastalıkları Ana Bilim Dalı
PROF.DR. İBRAHİM KARAYAYLALI
- Esansiyel (primer) hipertansiyonlu olgularda anjiyotensin dönüştürücü enzim (ACE) gen polimorfizmi ve hedef organ hasarına olan etkisi
Başlık çevirisi yok
İLKER EMİRCAN
Tıpta Uzmanlık
Türkçe
2005
RomatolojiEge Üniversitesiİç Hastalıkları Ana Bilim Dalı
PROF.DR. FEHMİ AKÇİÇEK