Sympathetic neural control of inflammation by ADRB2-mediatedIl-10 secretion
Başlık çevirisi mevcut değil.
- Tez No: 765276
- Danışmanlar: PROF. DR. J. DAVİD FARRAR
- Tez Türü: Doktora
- Konular: Biyomühendislik, Bioengineering
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2018
- Dil: İngilizce
- Üniversite: The Unıversıty Of Texas Southwestern Medıcal Center At Dallas
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Biyomedikal Bilimler ve Mühendislik Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
Özet yok.
Özet (Çeviri)
The nervous and immune systems reciprocally regulate their functions through the release of chemical messengers. Norepinephrine (NE), a neurotransmitter released by catecholaminergic nerve endings, allows the sympathetic nervous system to communicate with immune cells through adrenergic receptors (ADR). Although, the effects of adrenergic signaling has been studied in multiple cell types, its role in modulation of innate immune cells is relatively unknown. Here, I demonstrate a novel role for the b2-ADR (ADRB2) in controlling inflammation. NE suppresses pro-inflammatory cytokine secretion from primary macrophages in response to multiple TLR agonists, and ADRB2 signaling enhances early induction of IL-10. In addition to its in vitro affects, I have shown that ADRB2 signaling controls inflammation in vivo. The in vivo role of this pathway was assessed by using aninfection model, experimental colitis and LPS endotoxemia model. ADRB2-/- animals presented with splenomegaly and greater weight loss in infection and colitis, compared to ADRB2 sufficient animals, respectively. ADRB2-/- animals rapidly succumbed to a sublethal LPS challenge, which correlated with elevated serum levels of TNFα and reduced IL10. Administration of exogenous IL-10 increased the survival of the ADRB2-/- . Additionally, the ADRB2-specific agonist salmeterol rescued wild-type animals from a lethal LPS challenge, which was reversed by neutralizing anti-IL-10 antibody. These observations suggest that ADRB2 signaling is critical for controlling inflammation through the rapid induction of IL-10. Transcriptome analysis revealed that the NR4A nuclear orphan family members were induced by NE. The presence of several putative NR4A binding sites within the IL-10 promoter suggests that these factors may directly regulate IL-10 expression in response to ADRB2 signaling. Additionally, mice that deficient in NR4A1 are susceptible in LPS endotoxemia model. These results suggest a novel pathway for control of inflammation via neuroendocrine cues. Understanding this pathway will provide new insights into how the nervous and immune systems communicate through ADRB2 signaling
Benzer Tezler
- Tavşan kulağı modelinde intravasküler hyalüronik asit enjeksiyonuna bağlı gelişen iskemi tedavisinde hyalüronidaz ve tens uygulamasının etkinliklerinin karşılaştırılması
Comparison of the efficacy of hyaluronidase and tens application in the treatment of ischemia due to intravascular hyaluronic acid injection in the rabbit ear model
ERDİ KAYA
Tıpta Uzmanlık
Türkçe
2024
Plastik ve Rekonstrüktif CerrahiMersin ÜniversitesiPlastik Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
PROF. DR. ŞAKİR ÜNAL
- Investigation the effects of hydrogen sulfide treatment on glia-mediated neuroinflammation in hypertension
Hipertansiyonda glia aracılı nöroinflamasyonda hidrojen sülfür tedavisinin etkilerinin araştırılması
BAŞAK DONERTAS
Doktora
İngilizce
2019
Eczacılık ve FarmakolojiEskişehir Osmangazi ÜniversitesiTıbbi Farmakoloji Ana Bilim Dalı
PROF. DR. BAŞAR SIRMAGÜL
- El ve ense sempatik deri yanıtları ile kan basıncı arasındaki ilişkinin araştırılması
Investigation of the relationship between hand and neck sympathetic skin responses with blood pressure
MERVE ÖNERLİ
Tıpta Uzmanlık
Türkçe
2020
NörolojiBolu Abant İzzet Baysal ÜniversitesiNöroloji Ana Bilim Dalı
PROF. DR. SERPİL YILDIZ
- Prediyabetik hastalarda sinir ileti çalışmaları ve sempatik deri cevaplarıyla erken dönem polinöropati ve sudomotor fonksiyonların araştırılması
Research of early stage polyneuropathy and sudomotor functions in prediabetics by using nerve conduction studies and sympathetic skin responses
MEHMET TÜRKAY KARCI
Tıpta Uzmanlık
Türkçe
2013
NörolojiHarran ÜniversitesiNöroloji Ana Bilim Dalı
PROF. DR. TAHİR KURTULUŞ YOLDAŞ
- Yapay sinir ağları ve bulanık mantık denklik ilişkilerini kullanarak kalp hızı değişkenliği analizi
Heart rate variability analysis using artificial neural networks and fuzzy equivalence relations
ELHOUCINE EL FATIMI
Yüksek Lisans
Türkçe
2018
Bilgisayar Mühendisliği Bilimleri-Bilgisayar ve KontrolPamukkale ÜniversitesiBilgisayar Mühendisliği Ana Bilim Dalı
PROF. DR. SEZAİ TOKAT