Köpeklerde deneysel olarak oluşturulan septik şokun sağaltımında Dobutamine, Flunixin, Meglumine, Methylprednisolone ve Enalapril'in etkileri
Başlık çevirisi mevcut değil.
- Tez No: 58874
- Danışmanlar: DOÇ. DR. HASAN BATMAZ
- Tez Türü: Doktora
- Konular: Veteriner Hekimliği, Veterinary Medicine
- Anahtar Kelimeler: Köpekler, Şok-septik, Dogs, Shock-septic
- Yıl: 1997
- Dil: Türkçe
- Üniversite: Uludağ Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Veterinerlik İç Hastalıkları Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
SUMMARY In experimentally septic shock induced dogs, establishment of early diagnostic criteria and comparison of the affects of different treatment combinations at the beginning of the septic shock were aimed in this study. Thirty dogs of both sexes and different ages were used in the study. To clinically and hematologically controlled each dogs, 5x1 09 Escherichia coli bacteria/kg were given via intravenous route and approximately within one hour the septic shock was induced. Five groups each composed of 6 dogs were designed, and to I th group (control group) only antibiotic and fluid therapy was performed. To rest of the groups, along with antibiotic and fluid therapy, at the beginning dobutamin (10 meg/kg/min, i.v.) was given. Additionally, methylprednisolone sodium succinate (in the shock phase 30 mg/kg, i.v.), flunixin meglumin (in the shock phase and 2 nd and 12 th hours of the shock 1.5 mg/kg, i.v.), and enalapril (after 24 th hour 0.5 mg/kg, Per oral in every 12 hours), were utilized to the III. rd, IV. th and V. th groups, respectively. All the dogs were examined regarding for clinical, hematological and biochemical parameters before and at the septic shock phase and also at the 1 st, 4 th. 12 th, 24 th, 36 th, 48 th, 72 nd, 96 th and 120 th hours after the application of first treatment. Plasma volume was calculated from hematocrit and hemoglobin values. During the septic shock high fever, increased heart and respiratory rates, weakned heart beat and peripheral pulse, prolonged capillary refilling time, leukopenia, neutropenia, thrombocytopenia, plasma volume decrease and increased hematocrit (p<0.001) hemoglobin (p<0.01) values, red blood cell counts, AST and lactic acid levels (pO.OOl) were observed.ÖZET Bu çalışmada deneysel olarak septik şok oluşturulan köpeklerde erken tanı kriterlerinin ortaya konması ve septik şokun başlangıcında farklı sağaltım kombinasyonları uygulanarak etkilerinin karşılaştırılması amaçlanmıştır. Çalışmada her iki cinsiyetten, farklı yaştan 30 melez köpek kullanıldı. Klinik ve hematolojik olarak kontrol edilen köpeklere intravenöz (i.v.) yolla 5x1 09 adet/kg'a E. coli verildi ve ortalama bir saatte septik şok oluşturuldu. Herbiri altışar köpek içeren 5 grup oluşturularak, I. gruba (kontrol grubu) yalnız antibiyotik ve sıvı sağaltımı uygulandı. II. gruba antibiyotik ve sıvı sağaltımı ile birlikte başlangıçta dobutamin (10 mcg/kg/dk, i.v.) verildi. II. Gruptaki sağaltım planına ilave olarak ta III. grupta metilprednisolon sodyum süksinat (şok anında 30 mg/kg, i.v.), IV. grupta flunixin meglumin (şok anı, 2. ve 12. saatlerde 1.5 mg/kg, i.v.) ve V. grupta enalapril (24. saatten itibaren 12 saatte bir 0.5 mg/kg, oral) kullanıldı. Tüm köpekler deneme öncesi, septik şok oluştuğunda, ilk sağaltımdan sonraki 1, 4, 12, 24, 36, 48, 72, 96 ve 120. saatlerde klinik, hematolojik ve biyokimyasal parametreler yönünden muayene edildi. Hematokrit ve hemoglobin değerlerinden plazma volümü hesaplandı. Septik şok anında yüksek ateş, kalp ve solunum frekansının artışı, kalp vurumlarının ve periferal nabız kalitesinin zayıflaması, kapillar dolma zamanının uzaması, lökopeni, nötropeni, trombositopeni, plazma volümünde azalma ve hematokrit (pO.001), hemoglobin (p<0.01), eritrosit, AST ve laktik asit düzeylerinin arttığı gözlendi (pO.001). Farklı sağaltım kombinasyonları uygulandıktan sonra, değerlendirilen parametrelerin bir çoğunda gruplar arasında ve gruplar içi önemli farklılıkların yanında, özellikle kapillar dolma zamanının II. grupta 24. saatten itibaren (pO.001),
Özet (Çeviri)
SUMMARY In experimentally septic shock induced dogs, establishment of early diagnostic criteria and comparison of the affects of different treatment combinations at the beginning of the septic shock were aimed in this study. Thirty dogs of both sexes and different ages were used in the study. To clinically and hematologically controlled each dogs, 5x1 09 Escherichia coli bacteria/kg were given via intravenous route and approximately within one hour the septic shock was induced. Five groups each composed of 6 dogs were designed, and to I th group (control group) only antibiotic and fluid therapy was performed. To rest of the groups, along with antibiotic and fluid therapy, at the beginning dobutamin (10 meg/kg/min, i.v.) was given. Additionally, methylprednisolone sodium succinate (in the shock phase 30 mg/kg, i.v.), flunixin meglumin (in the shock phase and 2 nd and 12 th hours of the shock 1.5 mg/kg, i.v.), and enalapril (after 24 th hour 0.5 mg/kg, Per oral in every 12 hours), were utilized to the III. rd, IV. th and V. th groups, respectively. All the dogs were examined regarding for clinical, hematological and biochemical parameters before and at the septic shock phase and also at the 1 st, 4 th. 12 th, 24 th, 36 th, 48 th, 72 nd, 96 th and 120 th hours after the application of first treatment. Plasma volume was calculated from hematocrit and hemoglobin values. During the septic shock high fever, increased heart and respiratory rates, weakned heart beat and peripheral pulse, prolonged capillary refilling time, leukopenia, neutropenia, thrombocytopenia, plasma volume decrease and increased hematocrit (p<0.001) hemoglobin (p<0.01) values, red blood cell counts, AST and lactic acid levels (pO.OOl) were observed.SUMMARY In experimentally septic shock induced dogs, establishment of early diagnostic criteria and comparison of the affects of different treatment combinations at the beginning of the septic shock were aimed in this study. Thirty dogs of both sexes and different ages were used in the study. To clinically and hematologically controlled each dogs, 5x1 09 Escherichia coli bacteria/kg were given via intravenous route and approximately within one hour the septic shock was induced. Five groups each composed of 6 dogs were designed, and to I th group (control group) only antibiotic and fluid therapy was performed. To rest of the groups, along with antibiotic and fluid therapy, at the beginning dobutamin (10 meg/kg/min, i.v.) was given. Additionally, methylprednisolone sodium succinate (in the shock phase 30 mg/kg, i.v.), flunixin meglumin (in the shock phase and 2 nd and 12 th hours of the shock 1.5 mg/kg, i.v.), and enalapril (after 24 th hour 0.5 mg/kg, Per oral in every 12 hours), were utilized to the III. rd, IV. th and V. th groups, respectively. All the dogs were examined regarding for clinical, hematological and biochemical parameters before and at the septic shock phase and also at the 1 st, 4 th. 12 th, 24 th, 36 th, 48 th, 72 nd, 96 th and 120 th hours after the application of first treatment. Plasma volume was calculated from hematocrit and hemoglobin values. During the septic shock high fever, increased heart and respiratory rates, weakned heart beat and peripheral pulse, prolonged capillary refilling time, leukopenia, neutropenia, thrombocytopenia, plasma volume decrease and increased hematocrit (p<0.001) hemoglobin (p<0.01) values, red blood cell counts, AST and lactic acid levels (pO.OOl) were observed.
Benzer Tezler
- Köpeklerde deneysel olarak oluşturulan vitamin D3 toksikasyonunun klinik, hematolojik, ultrasonografik ve biyokimyasal bulgularının değerlendirilmesi
Evaluation of clinical, hematological, ultrasonographical and biochemical findings in dogs with experimentally induced vitamin D3 toxication
FİKRİYE SÜZER
Doktora
Türkçe
1997
Veteriner HekimliğiUludağ ÜniversitesiVeterinerlik İç Hastalıkları Ana Bilim Dalı
DOÇ. DR. NİLÜFER AYTUĞ
- Köpeklerde deneysel olarak oluşturulan karaciğer toksikasyonlarında klinik , hematolojik, biyokimyasal ve ultrasonografik bulgular
Clinical, hematologic, biochemical and ultrasonographic findings in experimentally induced liver toxications in dogs
MEHMET TÜTÜNCÜ
Doktora
Türkçe
1998
Veteriner HekimliğiYüzüncü Yıl ÜniversitesiVeterinerlik İç Hastalıkları Ana Bilim Dalı
- Köpeklerde deneysel olarak oluşturulan karaciğer toksikasyonunun tanısında adenozin deaminazın önemi
The Significence of adenosine deaminase in experimental toxicosis of liver in dogs
NURİ ALTUĞ
Yüksek Lisans
Türkçe
1999
Veteriner HekimliğiYüzüncü Yıl ÜniversitesiVeterinerlik İç Hastalıkları Ana Bilim Dalı
PROF.DR. ZAHİD TEVFİK AĞAOĞLU
- Köpeklerde deneysel nefrotoksikozisde eritropoietin ve bazı hematolojik parametreler üzerine araştırmalar
Investigation on erythropoietin level and some blood parameters in experimental nephrotoxicosis in dogs
EBUBEKİR CEYLAN
Doktora
Türkçe
1998
Veteriner HekimliğiYüzüncü Yıl ÜniversitesiVeterinerlik İç Hastalıkları Ana Bilim Dalı
PROF. DR. ZAHİD TEVFİK AĞAOĞLU
- Köpeklerin termal yanıklarında antioksidanların yara iyileşmesi üzerine etkileri
The Effects of antioxidants on wound healing in thermal burns in dogs
KAMİL SAĞLAM
Doktora
Türkçe
1998
Veteriner HekimliğiYüzüncü Yıl ÜniversitesiVeterinerlik Cerrahisi Ana Bilim Dalı
DOÇ. DR. BAHTİYAR BAKIR