Fetal dokularda saptanan“mozaisizmin”prenatal tanıda önemi
Başlık çevirisi mevcut değil.
- Tez No: 40764
- Danışmanlar: DOÇ.DR. SEHER BAŞARAN
- Tez Türü: Yüksek Lisans
- Konular: Tıbbi Biyoloji, Medical Biology
- Anahtar Kelimeler: Embriyo, Kromozom düzensizlikleri, Mozaisizm, Prenatal teşhis, Embryo, Chromosome aberrations, Mosaicism, Prenatal diagnosis
- Yıl: 1994
- Dil: Türkçe
- Üniversite: İstanbul Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
88 frequency of pseudomosaicism ranged from 0. 64% to 1.1% in the amniotic fluid cell cultures and 0.47% to 1.0% in CVS cultures although the ratio of false - negative cases is reported as 0.19%; no such cases were observed in our series. In our series, pseudomosaicism was observed in 0.44% of amniocentesis and in 1.3% of CVS series. Confined placental mosaicism is reported as being in the range of 0.47% to 1%. This finding was observed 1.3% in our CVS series. The ratio of false - negative cases is reported as 0.97% ; the frequency of this finding was 1.3% in our series. MCC and mosaicism is more common in CVS cultures than in amniotic fluid cell cultures. To reduce the risk of MCC, a careful dissection and removal of maternal decidua in a chorionic villus sample is a must. When direct preparation is not available and a 46, XX cell line is observed in a long - term CVS culture, Q banding must be performed to distinguish maternal chromosomes from the fetal ones. In CVS applications, the results obtained only by DP shouldn't be interpretated as the final result since DP has a high false - negativity risk.89 If mosaicism is observed in the CVS studies, fetal tissues ( amniotic fluid and fetal blood ) and postnatal study of the placenta should be assessed. Sufficient number of metaphases and multiple culture plates should be analyzed not to miss mosaicism.88 frequency of pseudomosaicism ranged from 0. 64% to 1.1% in the amniotic fluid cell cultures and 0.47% to 1.0% in CVS cultures although the ratio of false - negative cases is reported as 0.19%; no such cases were observed in our series. In our series, pseudomosaicism was observed in 0.44% of amniocentesis and in 1.3% of CVS series. Confined placental mosaicism is reported as being in the range of 0.47% to 1%. This finding was observed 1.3% in our CVS series. The ratio of false - negative cases is reported as 0.97% ; the frequency of this finding was 1.3% in our series. MCC and mosaicism is more common in CVS cultures than in amniotic fluid cell cultures. To reduce the risk of MCC, a careful dissection and removal of maternal decidua in a chorionic villus sample is a must. When direct preparation is not available and a 46, XX cell line is observed in a long - term CVS culture, Q banding must be performed to distinguish maternal chromosomes from the fetal ones. In CVS applications, the results obtained only by DP shouldn't be interpretated as the final result since DP has a high false - negativity risk.
Özet (Çeviri)
89 If mosaicism is observed in the CVS studies, fetal tissues ( amniotic fluid and fetal blood ) and postnatal study of the placenta should be assessed. Sufficient number of metaphases and multiple culture plates should be analyzed not to miss mosaicism.88 frequency of pseudomosaicism ranged from 0. 64% to 1.1% in the amniotic fluid cell cultures and 0.47% to 1.0% in CVS cultures although the ratio of false - negative cases is reported as 0.19%; no such cases were observed in our series. In our series, pseudomosaicism was observed in 0.44% of amniocentesis and in 1.3% of CVS series. Confined placental mosaicism is reported as being in the range of 0.47% to 1%. This finding was observed 1.3% in our CVS series. The ratio of false - negative cases is reported as 0.97% ; the frequency of this finding was 1.3% in our series. MCC and mosaicism is more common in CVS cultures than in amniotic fluid cell cultures. To reduce the risk of MCC, a careful dissection and removal of maternal decidua in a chorionic villus sample is a must. When direct preparation is not available and a 46, XX cell line is observed in a long - term CVS culture, Q banding must be performed to distinguish maternal chromosomes from the fetal ones. In CVS applications, the results obtained only by DP shouldn't be interpretated as the final result since DP has a high false - negativity risk.89 If mosaicism is observed in the CVS studies, fetal tissues ( amniotic fluid and fetal blood ) and postnatal study of the placenta should be assessed. Sufficient number of metaphases and multiple culture plates should be analyzed not to miss mosaicism.
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