Bazı 2-(1-pirazolil) benzimidazol türevleri üzerinde çalışmalar
Başlık çevirisi mevcut değil.
- Tez No: 37938
- Danışmanlar: PROF.DR. M. FETHİ ŞAHİN
- Tez Türü: Yüksek Lisans
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Antifungal ajanlar, Benzimidazoller, Antifungal agents, Benzimidazoles
- Yıl: 1994
- Dil: Türkçe
- Üniversite: Gazi Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
- 57 - VII. SUMMARY Two compounds which bear 3-pyrazoline-5-one moiety at the position 2 have been found v&ry active against some yeast-like fungi in our previous study. In this study, synthesis of the two compounds (compounds 1,3) in addition to that of rabenzazole have been carried out and two new additional compounds which had similar chemical structure have been synthesized (compounds 2,4). The chemical structure of the compounds have been elucidated by their IR, NMR spectral and elemental analysis. All the compounds synthesized have been tested against yeast-like fungi Candida parapsilosis. Candida albicans. Candida stellatoidea. Candida pseudptropicalis.- 58 - Candida guilliermondii for antifungal activity purpose, and they have been found more active than rabenzazole against the fungi employed. Compounds 1,2 and 3 have been, found almost equally potent, to the standard, miconazole.
Özet (Çeviri)
- 57 - VII. SUMMARY Two compounds which bear 3-pyrazoline-5-one moiety at the position 2 have been found v&ry active against some yeast-like fungi in our previous study. In this study, synthesis of the two compounds (compounds 1,3) in addition to that of rabenzazole have been carried out and two new additional compounds which had similar chemical structure have been synthesized (compounds 2,4). The chemical structure of the compounds have been elucidated by their IR, NMR spectral and elemental analysis. All the compounds synthesized have been tested against yeast-like fungi Candida parapsilosis. Candida albicans. Candida stellatoidea. Candida pseudptropicalis.- 58 - Candida guilliermondii for antifungal activity purpose, and they have been found more active than rabenzazole against the fungi employed. Compounds 1,2 and 3 have been, found almost equally potent, to the standard, miconazole.
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