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1-[5-kloro-3H-benzoksazolin-2-on-3-il]asetil-2-(2/4-sübstitüe benzal) hidrazon türevlerinin sentezi, yapı aydınlatması ve biyolojik aktiviteleri üzerinde çalışmalar

Synthesis of 1-[5-chloro-3H-benzoxazoline-2-on-3-yl]acetyl-2(2/4-substituted benzal) hydrazone derivatives, their structure elucidations and biological activities

  1. Tez No: 163493
  2. Yazar: AHMET EMİN GECİKEN
  3. Danışmanlar: PROF.DR. ALİ ULVİ TOSUN
  4. Tez Türü: Yüksek Lisans
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2006
  8. Dil: Türkçe
  9. Üniversite: Gazi Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Farmasötik Kimya Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.

Özet (Çeviri)

91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.91 Table-2. The yields and the melting points of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2-(2/4-substituted benzal) hydrazone derivatives. CH2-C- NH-N=CH-^ The structure elucidation of the fourteen title compounds were done by means of their spectral analyses.92 The biological activity for anticonvulsant effectiveness were accomplished and results are given in Table 1. Table-1. Anticonvulsant activity results of the title l-[5-chloro- 3H-benzoxazolin-2-on-3-yl]acetyl-2- (2/4-substituted benzal)hydrazone derivatives. P<0.05, Dose: 100mg/kg intraperitonale As shown from Table-1, compounds 7 (2-OMe), 10 (2-Me), 11 (4-Me), 16 (4-Me) and 17 (4-NMe2) showed considerable anticonvulsant activity.

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